Skip to Main content Skip to Navigation
Journal articles

Caenorhabditis elegans, a Host to Investigate the Probiotic Properties of Beneficial Microorganisms

Abstract : Caenorhabditis elegans, a non-parasitic nematode emerges as a relevant and powerful candidate as an in vivo model for microorganisms-microorganisms and microorganisms-host interactions studies. Experiments have demonstrated the probiotic potential of bacteria since they can provide to the worm a longer lifespan, an increased resistance to pathogens and to oxidative or heat stresses. Probiotics are used to prevent or treat microbiota dysbiosis and associated pathologies but the molecular mechanisms underlying their capacities are still unknown. Beyond safety and healthy aspects of probiotics, C. elegans represents a powerful way to design large-scale studies to explore transkingdom interactions and to solve questioning about the molecular aspect of these interactions. Future challenges and opportunities would be to validate C. elegans as an in vivo tool for high-throughput screening of microorganisms for their potential probiotic use on human health and to enlarge the panels of microorganisms studied as well as the human diseases investigated.
Document type :
Journal articles
Complete list of metadata

https://hal.inrae.fr/hal-03151398
Contributor : Sabine Rossi <>
Submitted on : Monday, June 7, 2021 - 10:35:44 AM
Last modification on : Tuesday, June 8, 2021 - 3:08:32 AM

File

2020_Poupet_Front_Nutrition.pd...
Files produced by the author(s)

Identifiers

Collections

Citation

Cyril Poupet, Christophe Chassard, Adrien Nivoliez, Stéphanie Bornes. Caenorhabditis elegans, a Host to Investigate the Probiotic Properties of Beneficial Microorganisms. Frontiers in nutrition, Frontiers media, 2020, 7 (10), ⟨10.3389/fnut.2020.00135⟩. ⟨hal-03151398⟩

Share

Metrics

Record views

78

Files downloads

19