Fast-Growing Alveolar Echinococcosis Following Lung Transplantation - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Pathogens Year : 2020

Fast-Growing Alveolar Echinococcosis Following Lung Transplantation

Clarisse Dupont
  • Function : Author
Frédéric Grenouillet
Jean-Yves Mabrut
  • Function : Author
Frédérique Gay
  • Function : Author
Florence Persat
  • Function : Author
Martine Wallon
François Philit
  • Function : Author
Damien Dupont


Alveolar echinococcosis is a rare but life-threatening infection caused by the parasiteEchinococcus multilocularis. Its natural history is characterized by a slow parasitic growth over several years. Increased incidence and shorter development delay have been reported in immune-compromised patients. We report the reactivation of aborted lesions within 12 months of lung transplantation leading to a fast-growing aggressive hepatic lesion. Timely identification of alveolar echninococcosis allowed prompt albendazole treatment and radical surgery leading to a favorable outcome 42 months after transplantation. However, close clinical, serological and radiological monitoring is required to rule out relapses in the long term. The pre-existence of aborted self-limited lesions of alveolar echinococcosis and the possibility for their atypical rapid growth in patients undergoing profound immunosuppression should be known by healthcare providers, even if working in non-endemic areas.
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Dates and versions

hal-03154574 , version 1 (07-06-2021)



Clarisse Dupont, Frédéric Grenouillet, Jean-Yves Mabrut, Frédérique Gay, Florence Persat, et al.. Fast-Growing Alveolar Echinococcosis Following Lung Transplantation. Pathogens, 2020, 9 (9), pp.756. ⟨10.3390/pathogens9090756⟩. ⟨hal-03154574⟩
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