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Phytosterol vehicles used in a functional product modify carotenoid/cholesterol bioaccessibility and uptake by Caco-2 cells

Abstract : Functional foods containing dispersible phytosterols (DPs) are recommended to reduce cholesterol absorption in humans. However, only a few studies have been conducted on the effect of DP vehicles on carotenoid bioaccessibility and uptake by intestinal cells. On a previously developed fermented maize product containing both DPs and carotenoids, we aim to evaluate the effect of DPs encapsulated by maltodextrin on the carotenoid/phytosterol/cholesterol interactions during gastro-duodenal digestion. Thanks to maltodextrin properties, beta-carotene and lycopene bioaccessibilities were significantly improved by 40.2 +/- 1.4% while that of beta-cryptoxanthin decreased by 14 +/- 0.1%. Additionally, the presence of DPs reduced the cholesterol micellarization by 51.8 +/- 4.2%. Despite a slight decrease in carotenoid uptake caused by the DP vehicle, related to micelle size, an inhibition of cholesterol accumulation by Caco-2 cells was observed. These results highlighted the key role of maltodextrin as a vehicle of DPs on carotenoid and cholesterol absorption.
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https://hal.inrae.fr/hal-03158779
Contributor : Nelly Lucas <>
Submitted on : Thursday, March 4, 2021 - 10:24:16 AM
Last modification on : Tuesday, May 11, 2021 - 4:50:04 PM

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Magali Gies, Adrien Servent, Patrick Borel, Claudie Dhuique-Mayer. Phytosterol vehicles used in a functional product modify carotenoid/cholesterol bioaccessibility and uptake by Caco-2 cells. Journal of Functional Foods, Elsevier, 2020, 68, pp.103920. ⟨10.1016/j.jff.2020.103920⟩. ⟨hal-03158779⟩

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