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High Efficiency Activation of L-Type Ca 2+ Current by 5-HT in Human Atrial Myocytes

Abstract : In human atrial myocytes, serotonin rather than sympathetic, stimulation is more frequently associated with atrial fibrillation. So does the arrhythmogenic effect of serotonin result from the mechanism of action of the receptor or the context of its action upon cardiac myocytes? The capacity of agonists to produce cAMP followed the sequence 5-HT < Iso < Forskolin to increase ICaL with 5-HT = Iso = Forskolin. The simultaneous application of threshold concentrations of 5-HT and Iso maximally increased ICaL. We will show that the effect of 5-HT upon human atrial myocytes is an imbalance between low production of cAMP and maximal activation of ICaL.
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https://hal.inrae.fr/hal-03170825
Contributor : Eric Marchoux <>
Submitted on : Tuesday, March 16, 2021 - 2:40:11 PM
Last modification on : Friday, April 9, 2021 - 12:54:06 PM

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Emmanuella Di Scala, Ian Findlay, Stephanie Rose, Michel Aupart, Jorge Argibay, et al.. High Efficiency Activation of L-Type Ca 2+ Current by 5-HT in Human Atrial Myocytes. Receptors and Channels, Informa UK (Taylor & Francis), 2011, 10 (5-6), pp.159-165. ⟨10.3109/10606820490926115⟩. ⟨hal-03170825⟩

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