Salinization is a major soil degradation threat in irrigated systems worldwide. Irrigated systems in the Niger River basin are also affected by salinity, but its spatial distribution and intensity are not currently known. The aim of this study was to develop a method to detect salt-affected soils in irrigated systems. Two complementary approaches were tested: salinity assessment of bare soils using a salinity index (SI) and monitoring of indirect effects of salinity on rice growth using temporal series of a vegetation index (NDVI). The study area was located south of Niamey (Niger) in two irrigated systems of rice paddy fields that cover 6.5 km(2). We used remote-sensing and ground-truth data to relate vegetation behavior and reflectance to soil characteristics. We explored all existing Sentinel-2 images from January 2016 to December 2019 and selected cloud-free images on 157 dates that covered eight successive rice-growing seasons. In the dry season of 2019, we also sampled 44 rice fields, collecting 147 biomass samples and 180 topsoil samples from January to June. For each field and growing season, time-integrated NDVI (TI-NDVI) was estimated, and the SI was calculated for dates on which bare soil conditions (NDVI < 0.21) prevailed. Results showed that since there were few periods of bare soil, SI could not differentiate salinity classes. In contrast, the high temporal resolution of Sentinel-2 images enabled us to describe rice-growing conditions over time. In 2019, TI-NDVI and crop yields were strongly correlated (r = 0.77 with total biomass yield and 0.82 with grain yield), while soil electrical conductivity was negatively correlated with both TI-NDVI (r = -0.38) and crop yield (r = -0.23 with total biomass and r = -0.29 with grain yield). Considering the TI-NDVI data from 2016-2019, principal component analysis followed by ascending hierarchical classification identified a typology of five clusters with different patterns of TI-NDVI during the eight growing seasons. When applied to the entire study area, this classification clearly identified the extreme classes (i.e., areas with high or no salinity). Other classes with low TI-NDVI (i.e., during dry seasons) may be related to areas with moderate or seasonal soil salinity. Finally, the high temporal resolution of Sentinel-2 images enabled us to detect stresses on vegetation that occurred repeatedly over the growing seasons, which may be good indicators of soil constraints due to salinity in the context of the irrigated paddy systems of Niger. Further research will validate the ability of the method developed to detect moderate soil salinity constraints over large areas.