Skip to Main content Skip to Navigation
Journal articles

The influence of nutrigenetics on biomarkers of selenium nutritional status

Abstract : Selenium (Se) is an essential micronutrient for human biology that executes its functions as the amino acid selenocysteine via selenoproteins, which have important functions, such as, antioxidant, immunomodulatory, thyroid metabolism and human fertility. Se nutritional status is assessed using the quantification of blood Se biomarkers influenced by several factors, including diet, age, gender, smoking status, alcohol consumption, health condition and genetic characteristics of individuals. Nutrigenetic studies have identified single nucleotide polymorphisms (SNPs) in 2 selenoproteins that might clarify the high variability in values reported for biomarkers of Se nutritional status in different populations and the response of these biomarkers to Se supplementation with either organic or inorganic forms of Se. This review aims to (1) define the basic aspects of Se biology, (2) describe the current most commonly used biomarkers of Se nutritional status and, (3) provide a state of the art of associations observed between functional SNPs in selenoproteins and biomarkers of Se status in healthy populations.
Complete list of metadata
Contributor : Patrick Borel Connect in order to contact the contributor
Submitted on : Tuesday, April 20, 2021 - 11:08:48 AM
Last modification on : Sunday, June 26, 2022 - 10:18:05 AM
Long-term archiving on: : Wednesday, July 21, 2021 - 11:51:26 PM


Donadio Nutr Rev 2021 HAL.pdf
Files produced by the author(s)




Janaina L S Donadio, Graziela B S Duarte, Patrick A Borel, Silvia M F Cozzolino, Marcelo M. Rogero. The influence of nutrigenetics on biomarkers of selenium nutritional status. Nutrition Reviews, Oxford University Press (OUP), 2021, ⟨10.1093/nutrit/nuaa136⟩. ⟨hal-03202767⟩



Record views


Files downloads