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PROTEIN PHOSPHATASE 2A-B′ γ Controls Botrytis cinerea Resistance and Developmental Leaf Senescence

Abstract : Plants optimize their growth and survival through highly integrated regulatory networks that coordinate defensive measures and developmental transitions in response to environmental cues. Protein phosphatase 2A (PP2A) is a key signaling component that controls stress reactions and growth at different stages of plant development, and the PP2A regulatory subunit PP2A-B'gamma is required for negative regulation of pathogenesis responses and for maintenance of cell homeostasis in short-day conditions. Here, we report molecular mechanisms by which PP2A-B'gamma regulates Botrytis cinerea resistance and leaf senescence in Arabidopsis (Arabidopsis thaliana). We extend the molecular functionality of PP2A-B'gamma to a protein kinase-phosphatase interaction with the defense-associated calcium-dependent protein kinase CPK1 and present indications this interaction may function to control CPK1 activity. In presenescent leaf tissues, PP2A-B'gamma is also required to negatively control the expression of salicylic acid-related defense genes, which have recently proven vital in plant resistance to necrotrophic fungal pathogens. In addition, we find the premature leaf yellowing of pp2a-b'gamma depends on salicylic acid biosynthesis via SALICYLIC ACID INDUCTION DEFICIENT2 and bears the hallmarks of developmental leaf senescence. We propose PP2A-B'gamma age-dependently controls salicylic acid-related signaling in plant immunity and developmental leaf senescence.
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https://hal.inrae.fr/hal-03219250
Contributor : Christopher Lallemant <>
Submitted on : Thursday, May 6, 2021 - 11:44:22 AM
Last modification on : Thursday, June 10, 2021 - 11:40:25 AM

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Guido Durian, Verena Jeschke, Moona Rahikainen, Katariina Vuorinen, Peter Gollan, et al.. PROTEIN PHOSPHATASE 2A-B′ γ Controls Botrytis cinerea Resistance and Developmental Leaf Senescence. Plant Physiology, American Society of Plant Biologists, 2020, 182 (2), pp.1161-1181. ⟨10.1104/pp.19.00893⟩. ⟨hal-03219250⟩

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