Skip to Main content Skip to Navigation
Journal articles

Interactions of bile salts with a dietary fibre, methylcellulose, and impact on lipolysis

Abstract : Methylcellulose (MC) has a demonstrated capacity to reduce fat absorption, hypothetically through bile salt (BS) activity inhibition. We investigated MC cholesterol-lowering mechanism, and compared the influence of two BS, sodium taurocholate (NaTC) and sodium taurodeoxycholate (NaTDC), which differ slightly by their architecture and exhibit contrasting functions during lipolysis. BS/MC bulk interactions were investigated by rheology, and BS behaviour at the MC/water interface studied with surface pressure and ellipsometry measurements. In vitro lipolysis studies were performed to evaluate the effect of BS on MC-stabilised emulsion droplets microstructure, with confocal microscopy, and free fatty acids release, with the pH-stat method. Our results demonstrate that BS structure dictates their interactions with MC, which, in turn, impact lipolysis. Compared to NaTC, NaTDC alters MC viscoelasticity more significantly, which may correlate with its weaker ability to promote lipolysis, and desorbs from the interface at lower concentrations, which may explain its higher propensity to destabilise emulsions.
Document type :
Journal articles
Complete list of metadata
Contributor : Myriam Grundy <>
Submitted on : Friday, May 21, 2021 - 9:42:19 AM
Last modification on : Thursday, May 27, 2021 - 4:55:00 PM

Links full text




Olivia Pabois, Amandine Antoine-Michard, Xi Zhao, Jasmin Omar, Faizah Ahmed, et al.. Interactions of bile salts with a dietary fibre, methylcellulose, and impact on lipolysis. Carbohydrate Polymers, Elsevier, 2020, 231, pp.115741. ⟨10.1016/j.carbpol.2019.115741⟩. ⟨hal-03231688⟩



Record views