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Fermentation of Ferulated Arabinoxylan Recovered from the Maize Bioethanol Industry

Abstract : Maize by-product from the bioethanol industry (distiller’s dried grains with solubles, DDGS) is a source of ferulated arabinoxylan (AX), which is a health-promoting polysaccharide. In the present study, AX from DDGS was fermented by a representative colonic bacterial mixture (Bifidobacterium longum, Bifidobacterium adolescentis, and Bacteroides ovatus), and the effect of the fermented AX (AX-f) on the proliferation of the cell line Caco-2 was investigated. AX was efficiently metabolized by these bacteria, as evidenced by a decrease in the polysaccharide molecular weight from 209 kDa to < 50 kDa in AX-f, the release of ferulic acid (FA) from polysaccharide chains (1.14 µg/mg AX-f), and the short-chain fatty acids (SCFA) production (277 µmol/50 mg AX). AX-f inhibited the proliferation of Caco-2 cells by 80–40% using concentrations from 125–1000 µg/mL. This dose-dependent inverse effect was attributed to the increased viscosity of the media due to the polysaccharide concentration. The results suggest that the AX-f dose range and the SCFA and free FA production are key determinants of antiproliferative activity. Using the same polysaccharide concentrations, non-fermented AX only inhibited the Caco-2 cells proliferation by 8%. These findings highlight the potential of AX recovered from the maize bioethanol industry as an antiproliferative agent once fermented by colonic bacteria
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Submitted on : Sunday, June 6, 2021 - 10:12:38 PM
Last modification on : Friday, May 20, 2022 - 9:04:17 AM


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Mayra A Mendez-Encinas, Dora E Valencia-Rivera, Elizabeth Carvajal-Millan, Humberto Astiazaran-Garcia, Valérie Micard, et al.. Fermentation of Ferulated Arabinoxylan Recovered from the Maize Bioethanol Industry. Processes, MDPI, 2021, 9 (1), pp.165. ⟨10.3390/pr9010165⟩. ⟨hal-03251277⟩



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