Skip to Main content Skip to Navigation
Journal articles

mTOR-driven glycolysis governs induction of innate immune responses by bronchial epithelial cells exposed to the bacterial component flagellin

Abstract : Human bronchial epithelial (HBE) cells play an essential role during bacterial infections of the airways by sensing pathogens and orchestrating protective immune responses. We here sought to determine which metabolic pathways are utilized by HBE cells to mount innate immune responses upon exposure to a relevant bacterial agonist. Stimulation of HBE cells by the bacterial component flagellin triggered activation of the mTOR pathway resulting in an increased glycolytic flux that sustained the secretory activity of immune mediators by HBE cells. The mTOR inhibitor rapamycin impeded glycolysis and limited flagellin-induced secretion of immune mediators. The role of the mTOR pathway was recapitulated in vivo in a mouse model of flagellin-triggered lung innate immune responses. These data demonstrate that metabolic reprogramming via the mTOR pathway modulates activation of the respiratory epithelium, identifying mTOR as a potential therapeutic target to modulate mucosal immunity in the context of bacterial infections.
Document type :
Journal articles
Complete list of metadata

https://hal.inrae.fr/hal-03258194
Contributor : Jean-Claude Sirard <>
Submitted on : Friday, June 11, 2021 - 1:39:18 PM
Last modification on : Saturday, June 12, 2021 - 3:35:12 AM

Identifiers

Collections

Citation

I. Ramirez-Moral, X. Yu, J. Butler, M. van Weeghel, N. Otto, et al.. mTOR-driven glycolysis governs induction of innate immune responses by bronchial epithelial cells exposed to the bacterial component flagellin. Mucosal Immunology, Nature Pub. Group, 2021, 14 (3), pp.594-604. ⟨10.1038/s41385-021-00377-8⟩. ⟨hal-03258194⟩

Share

Metrics

Record views

27