Gene-rich UV sex chromosomes harbor conserved regulators of sexual development - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Science Advances Year : 2021

Gene-rich UV sex chromosomes harbor conserved regulators of sexual development

Sarah Carey
  • Function : Author
Jerry Jenkins
  • Function : Author
John Lovell
  • Function : Author
Florian Maumus
Avinash Sreedasyam
  • Function : Author
Adam Payton
  • Function : Author
Shengqiang Shu
  • Function : Author
George Tiley
  • Function : Author
Noe Fernandez-Pozo
  • Function : Author
Adam Healey
  • Function : Author
Kerrie Barry
Cindy Chen
  • Function : Author
Mei Wang
  • Function : Author
Anna Lipzen
Chris Daum
  • Function : Author
Christopher Saski
  • Function : Author
Jordan Mcbreen
  • Function : Author
Roth Conrad
  • Function : Author
Leslie Kollar
  • Function : Author
Sanna Olsson
  • Function : Author
Sanna Huttunen
  • Function : Author
Jacob Landis
  • Function : Author
J. Gordon Burleigh
  • Function : Author
Norman Wickett
  • Function : Author
Matthew Johnson
Stefan Rensing
Jane Grimwood
  • Function : Author
Jeremy Schmutz
  • Function : Author
Stuart Mcdaniel
  • Function : Author

Abstract

Nonrecombining sex chromosomes, like the mammalian Y, often lose genes and accumulate transposable elements, a process termed degeneration. The correlation between suppressed recombination and degeneration is clear in animal XY systems, but the absence of recombination is confounded with other asymmetries between the X and Y. In contrast, UV sex chromosomes, like those found in bryophytes, experience symmetrical population genetic conditions. Here, we generate nearly gapless female and male chromosome-scale reference genomes of the moss Ceratodon purpureus to test for degeneration in the bryophyte UV sex chromosomes. We show that the moss sex chromosomes evolved over 300 million years ago and expanded via two chromosomal fusions. Although the sex chromosomes exhibit weaker purifying selection than autosomes, we find that suppressed recombination alone is insufficient to drive degeneration. Instead, the U and V sex chromosomes harbor thousands of broadly expressed genes, including numerous key regulators of sexual development across land plants.

Dates and versions

hal-03283299 , version 1 (09-07-2021)

Licence

Attribution - NonCommercial

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Sarah Carey, Jerry Jenkins, John Lovell, Florian Maumus, Avinash Sreedasyam, et al.. Gene-rich UV sex chromosomes harbor conserved regulators of sexual development. Science Advances , 2021, 7 (27), pp.1-12. ⟨10.1126/sciadv.abh2488⟩. ⟨hal-03283299⟩
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