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Poster communications

Host genetic contribution to understand the susceptibility to cryptosporidium parvum infection

Abstract : Cryptosporidium parvum is a zoonotic apicomplexan parasite responsible for a diarrheal disease named cryptosporidiosis. The immature intestinal immune system in very young animals and children under 5 placesthem at high risk of developing severe cryptosporidiosis(Laurent, Lacroix‐Lamandé, Int. J. Parasitol. 2017).In order to identify susceptibility and resistance factors to cryptosporidiosis, we investigated the difference in susceptibility to Cryptosporidium parvum infection in five inbred mouse lines with well‐defined genetics (C57BL/6, BALB/c, CBA, DBA/2 and C3H/HeN). The parasitic load analysis of young mice at the peak of infection allowed us to clearly distinguish sensitivity differences gathered in three groups (BALB/c S+++, C57BL/6 S++, C3H/HeN S+). We next deciphered the mechanisms responsible for this difference by using these three strains of mice and by comparing some physiological and immunological parameters. At this stage, two elements emerge from our first analyzes: a difference in the recruitment of CD11c+ MHCII+ CD64+ Ly6c+ inflammatory monocytes in C3H/HeN mice and a difference in the expression of the antimicrobial peptide, Reg3γ, which is strongly overexpressed after infection in C3H/HeN mice.This project is part of the multi‐partner project APIS‐GENE "Healthycalf" which aims to identify neonatal susceptibility biomarkers in calves.
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Poster communications
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https://hal.inrae.fr/hal-03310151
Contributor : Nathalie Katy Chanteloup <>
Submitted on : Friday, July 30, 2021 - 12:35:54 PM
Last modification on : Saturday, July 31, 2021 - 3:55:08 AM

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  • HAL Id : hal-03310151, version 1

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Tiffany Pézier, Maëva Eloudzeri, Sonia Lacroix-Lamandé, Fabrice Laurent. Host genetic contribution to understand the susceptibility to cryptosporidium parvum infection. Journées d'animation scientifique de la Fédération de Recherche en Infectiologie (FéRI), Oct 2019, Tours, France. pp.50. ⟨hal-03310151⟩

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