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Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aphid crop pest Myzus persicae

Kumar Saurabh Singh 1 Erick Cordeiro 2 Bartlomiej Troczka 1 Adam Pym 1 Joanna Mackisack 1 Thomas Mathers 3 Ana Duarte 1 Fabrice Legeai 4 Stéphanie Robin 4 Pablo Bielza 5 Hannah Burrack 6 Kamel Charaabi 7 Ian Denholm 8 Christian Figueroa 9 Richard Ffrench-Constant 1 Georg Jander 10 John Margaritopoulos 11 Emanuele Mazzoni 12 Ralf Nauen 13 Claudio Ramírez 9 Guangwei Ren 14 Ilona Stepanyan 15 Paul Umina 16 Nina Voronova 17 John Vontas 18, 19 Martin Williamson 20 Alex Wilson 21 Gao Xi-Wu 22 Young-Nam Youn 23 Christoph Zimmer 1 Jean-Christophe Simon 4 Alex Hayward 1 Chris Bass 1
Abstract : Abstract The aphid Myzus persicae is a destructive agricultural pest that displays an exceptional ability to develop resistance to both natural and synthetic insecticides. To investigate the evolution of resistance in this species we generated a chromosome-scale genome assembly and living panel of >110 fully sequenced globally sampled clonal lines. Our analyses reveal a remarkable diversity of resistance mutations segregating in global populations of M. persicae . We show that the emergence and spread of these mechanisms is influenced by host–plant associations, uncovering the widespread co‐option of a host-plant adaptation that also offers resistance against synthetic insecticides. We identify both the repeated evolution of independent resistance mutations at the same locus, and multiple instances of the evolution of novel resistance mechanisms against key insecticides. Our findings provide fundamental insights into the genomic responses of global insect populations to strong selective forces, and hold practical relevance for the control of pests and parasites.
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https://hal.inrae.fr/hal-03313531
Contributor : Anne-Sophie Grenier <>
Submitted on : Wednesday, August 4, 2021 - 11:14:30 AM
Last modification on : Friday, August 6, 2021 - 3:12:57 AM

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Kumar Saurabh Singh, Erick Cordeiro, Bartlomiej Troczka, Adam Pym, Joanna Mackisack, et al.. Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aphid crop pest Myzus persicae. Communications Biology, Nature Publishing Group, 2021, 4 (1), ⟨10.1038/s42003-021-02373-x⟩. ⟨hal-03313531⟩

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