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Article Dans Une Revue (Article De Synthèse) The World Journal of Men's Health Année : 2021

Relevance of Leukocytospermia and Semen Culture and Its True Place in Diagnosing and Treating Male Infertility

Rakesh Sharma
Sajal Gupta
Ashok Agarwal
Renata Finelli
Neel Parekh
Ramadan Saleh
Edmund Ko
Rupin Shah
Rafael Ambar
  • Fonction : Auteur
Haitham Elbardisi
Pallav Sengupta
Marlon Martinez
Paraskevi Vogiatzi
Jaime Gosalvez
Parviz Kavoussi
Hussein Kandil
Ayad Palani
Marcelo Rodriguez Peña
  • Fonction : Auteur
Osvaldo Rajmil
Gian Maria Busetto
Christina Anagnostopoulou
Sava Micic
Taymour Mostafa
Juan Alvarez
Sunil Jindal
Israel Maldonado Rosas
  • Fonction : Auteur
Sheena E.M. Lewis
  • Fonction : Auteur
Sami Alsaid
  • Fonction : Auteur
Hyun Jun Park
Giovanni Colpi

Résumé

The current WHO 2010 manual for human semen analysis defines leukocytospermia as the presence of peroxidase-positive leukocytes at a concentration >1×106/mL of semen. Granular leukocytes when activated are capable of generating high levels of reactive oxygen species in semen resulting in oxidative stress. Oxidative stress has been correlated with poor sperm quality, increased level of sperm DNA fragmentation and low fertility potential. The presence of leukocytes and pathogens in the semen may be a sign of infection and/or localized inflammatory response in the male genital tract and the accessory glands. Common uro-pathogens including Chlamydia trachomatis, Ureaplasma urealyticum, Neisseria gonorrhoeae, Mycoplasma hominis, and Escherichia coli can cause epididymitis, epididymo-orchitis, or prostatitis. The relationship between leukocytospermia and infection is unclear. Therefore, we describe the pathogens responsible for male genital tract infections and their association with leukocytospermia. The review also examines the diagnostic tests available to identify seminal leukocytes. The role of leukocytospermia in male infertility and its management is also discussed.
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hal-03324952 , version 1 (01-06-2022)

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Paternité - Pas d'utilisation commerciale

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Rakesh Sharma, Sajal Gupta, Ashok Agarwal, Ralf Henkel, Renata Finelli, et al.. Relevance of Leukocytospermia and Semen Culture and Its True Place in Diagnosing and Treating Male Infertility. The World Journal of Men's Health, 2021, 39, ⟨10.5534/WJMH.210063⟩. ⟨hal-03324952⟩
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