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The PPARβ/δ-AMPK Connection in the Treatment of Insulin Resistance

Abstract : The current treatment options for type 2 diabetes mellitus do not adequately control the disease in many patients. Consequently, there is a need for new drugs to prevent and treat type 2 diabetes mellitus. Among the new potential pharmacological strategies, activators of peroxisome proliferator-activated receptor (PPAR)β/δ show promise. Remarkably, most of the antidiabetic effects of PPARβ/δ agonists involve AMP-activated protein kinase (AMPK) activation. This review summarizes the recent mechanistic insights into the antidiabetic effects of the PPARβ/δ-AMPK pathway, including the upregulation of glucose uptake, muscle remodeling, enhanced fatty acid oxidation, and autophagy, as well as the inhibition of endoplasmic reticulum stress and inflammation. A better understanding of the mechanisms underlying the effects resulting from the PPARβ/δ-AMPK pathway may provide the basis for the development of new therapies in the prevention and treatment of insulin resistance and type 2 diabetes mellitus.
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Contributor : Hélène Lesur <>
Submitted on : Monday, August 30, 2021 - 11:31:07 AM
Last modification on : Wednesday, September 15, 2021 - 10:05:43 AM


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David Aguilar-Recarte, Xavier Palomer, Walter Wahli, Manuel Vázquez-Carrera. The PPARβ/δ-AMPK Connection in the Treatment of Insulin Resistance. International Journal of Molecular Sciences, MDPI, 2021, 22 (16), pp.8555. ⟨10.3390/ijms22168555⟩. ⟨hal-03328633⟩



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