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European Task Force on Atopic Dermatitis (ETFAD): treatment targets and treatable traits in atopic dermatitis

J.P. Thyssen 1, 2, * C. Vestergaard 3 M. Deleuran 3 M.S. Bruin‐weller 4 T. Bieber 5 A. Taieb 6 J. Seneschal 6 M.J. Cork 7 C. Paul 8 C. Flohr 9 S. Weidinger 10 M. Trzeciak 11 T. Werfel 12 A. Heratizadeh 12 S. Barbarot 13 U. Darsow 14 D. Simon 15 A. Torrelo 16 P.V. Chernyshov 17 J.‐f. Stalder 18 C. Gelmetti 19 Z. Szalai 20 Å. Svensson 21 L.B. Kobyletzki 21 L. de Raeve 22 R. Fölster‐holst 23 S. Cristen‐zaech 24 D. Hijnen 25 U. Gieler 13 J. Ring 26 A. Wollenberg 27
Abstract : Background: Surgery is a radical treatment for hidradenitis suppurativa (HS) and may be considered as the only one potentially curative. Objectives: To characterize HS recurrence in patients after surgery and assess the risk factors of recurrence. Methods: We conducted a monocentric retrospective cohort study. All consecutive patients who had surgery (January 1, 2012 to March 31, 2017) were included. We estimated the rate of recurrence of HS lesions after surgery (<1 cm from the scar), and recurrence-associated factors were analysed by univariate then multivariate logistic regression, estimating odds ratios (ORs) and 95% confidence intervals (CIs). Results: A total of 75 patients [median age 31.4 years (range 16–71); 36 females], corresponding to 115 interventions were included. The Hurley score at surgery was III for 70 (60%) patients. In total, 61/115 (53%) interventions involved wide excision and 50 (43%) limited local excision. The localizations were axillary folds (n = 46; 40%), buttocks (n = 15, 13%), genital area (n = 13; 11%), perineal area (n = 12; 10%) and inguinal folds (n = 18; 16%). We observed 11 (10%) complications and 40 (35%) recurrences. On multivariate analysis, probability of recurrence was associated with only one-stage surgical closure [OR 3.2 (95% CI 1.4–7.3), P = 0.005]. Overall, 44 (52%) patients were completely satisfied and 22 (26%) partially satisfied, and most (81%) considered the surgery the best treatment. Conclusions: Hidradenitis suppurativa recurrence in our study was 35% and associated with one-stage surgical closures, but two-thirds of patients were satisfied with surgical treatment and would recommend surgery.
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Submitted on : Thursday, September 9, 2021 - 9:38:55 AM
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J.P. Thyssen, C. Vestergaard, M. Deleuran, M.S. Bruin‐weller, T. Bieber, et al.. European Task Force on Atopic Dermatitis (ETFAD): treatment targets and treatable traits in atopic dermatitis. Journal of the European Academy of Dermatology and Venereology, Wiley, 2020, 34 (12), pp.E839-E842. ⟨10.1111/jdv.16716⟩. ⟨hal-03338814⟩

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