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The VP3 Protein of Bluetongue Virus Associates with the MAVS Complex and Interferes with the RIG-I-Signaling Pathway

Abstract : Bluetongue virus (BTV), an arbovirus transmitted by Culicoides biting midges, is a major concern of wild and domestic ruminants. While BTV induces type I interferon (alpha/beta interferon [IFN-α/β]) production in infected cells, several reports have described evasion strategies elaborated by this virus to dampen this intrinsic, innate response. In the present study, we suggest that BTV VP3 is a new viral antagonist of the IFN-β synthesis. Indeed, using split luciferase and coprecipitation assays, we report an interaction between VP3 and both the mitochondrial adapter protein MAVS and the IRF3-kinase IKKε. Overall, this study describes a putative role for the BTV structural protein VP3 in the control of the antiviral response.
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https://hal.inrae.fr/hal-03348961
Contributor : Christopher Lallemant Connect in order to contact the contributor
Submitted on : Monday, September 20, 2021 - 10:40:13 AM
Last modification on : Friday, October 8, 2021 - 4:06:07 PM

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Marie Pourcelot, Rayane Amaral Moraes, Aurore Fablet, Emmanuel Bréard, Corinne Sailleau, et al.. The VP3 Protein of Bluetongue Virus Associates with the MAVS Complex and Interferes with the RIG-I-Signaling Pathway. Viruses, MDPI, 2021, 13 (2), pp.230. ⟨10.3390/v13020230⟩. ⟨hal-03348961⟩

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