The VP3 Protein of Bluetongue Virus Associates with the MAVS Complex and Interferes with the RIG-I-Signaling Pathway - Archive ouverte HAL Access content directly
Journal Articles Viruses Year : 2021

The VP3 Protein of Bluetongue Virus Associates with the MAVS Complex and Interferes with the RIG-I-Signaling Pathway

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Aurore Fablet
  • Function : Author
Cyril Viarouge
  • Function : Author
Lydie Postic
  • Function : Author
Stéphan Zientara
Grégory Caignard
Damien Vitour
  • Function : Correspondent author

Abstract

Bluetongue virus (BTV), an arbovirus transmitted by Culicoides biting midges, is a major concern of wild and domestic ruminants. While BTV induces type I interferon (alpha/beta interferon [IFN-α/β]) production in infected cells, several reports have described evasion strategies elaborated by this virus to dampen this intrinsic, innate response. In the present study, we suggest that BTV VP3 is a new viral antagonist of the IFN-β synthesis. Indeed, using split luciferase and coprecipitation assays, we report an interaction between VP3 and both the mitochondrial adapter protein MAVS and the IRF3-kinase IKKε. Overall, this study describes a putative role for the BTV structural protein VP3 in the control of the antiviral response.

Dates and versions

hal-03348961 , version 1 (20-09-2021)

Licence

Attribution - CC BY 4.0

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Cite

Marie Pourcelot, Rayane Amaral Moraes, Aurore Fablet, Emmanuel Bréard, Corinne Sailleau, et al.. The VP3 Protein of Bluetongue Virus Associates with the MAVS Complex and Interferes with the RIG-I-Signaling Pathway. Viruses, 2021, 13 (2), pp.230. ⟨10.3390/v13020230⟩. ⟨hal-03348961⟩
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