Fecal Serine Protease Profiling in Inflammatory Bowel Diseases - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Frontiers in Cellular and Infection Microbiology Year : 2020

Fecal Serine Protease Profiling in Inflammatory Bowel Diseases

Abstract

Serine proteases are extensively known to play key roles in many physiological processes. However, their dysregulation is often associated to several diseases including inflammatory bowel diseases (IBD). Here, we used specific substrates to monitor fecal protease activities in a large cohort of healthy and IBD patients. Of interest, serine protease activity was 10-fold higher in IBD fecal samples compared to healthy controls. Moreover, functional analysis of these fecal proteolytic activities revealed that the most increased activities are trypsin-like, elastase-like and cathepsin G-like. We also show for the first time, an increase of proteinase 3-like activity in these samples compared to controls. Results presented here will guide further investigations to better understand the relevance of these peptidases in IBD.

Dates and versions

hal-03372023 , version 1 (09-10-2021)

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Amin Jablaoui, Aicha Kriaa, Héla Mkaouar, Nizar Akermi, Souha Soussou, et al.. Fecal Serine Protease Profiling in Inflammatory Bowel Diseases. Frontiers in Cellular and Infection Microbiology, 2020, 10, ⟨10.3389/fcimb.2020.00021⟩. ⟨hal-03372023⟩
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