Are Physicochemical Properties Shaping the Allergenic Potency of Animal Allergens?
Joana Costa
(1)
,
Caterina Villa
(1)
,
Kitty Verhoeckx
(2)
,
Tanja Cirkovic-Velickovic
(3)
,
Denise Schrama
(4)
,
Paola Roncada
(5)
,
Pedro Rodrigues
(6)
,
Cristian Piras
(7)
,
Laura Martín-Pedraza
(8)
,
Linda Monaci
(9)
,
Elena Molina
(10)
,
Gabriel Mazzucchelli
(11)
,
Isabel Mafra
(12)
,
Roberta Lupi
(13)
,
Daniel Lozano-Ojalvo
(14)
,
Colette Larré
(13)
,
Julia Klueber
(15)
,
Eva Gelencser
(16)
,
Cristina Bueno-Diaz
(8)
,
Araceli Diaz-Perales
(17)
,
Sara Benedé
(10)
,
Simona Lucia Bavaro
(18)
,
Annette Kuehn
(15)
,
Karin Hoffmann-Sommergruber
(19)
,
Thomas Holzhauser
(20)
1
UC -
University of Coimbra [Portugal]
2 TNO
3 University of Belgrade [Belgrade]
4 UAlg - Universidade do Algarve
5 UMG - Università degli Studi "Magna Graecia" di Catanzaro = University of Catanzaro
6 EM2C - Laboratoire d'Énergétique Moléculaire et Macroscopique, Combustion
7 Department of Chemistry
8 UCM - Universidad Complutense de Madrid = Complutense University of Madrid [Madrid]
9 ISPA - Institute of Sciences of Food Production
10 CIAL - Instituto de Investigación en Ciencias de la Alimentación
11 Laboratory of Mass Spectrometry-GIGA-Proteomics
12 REQUIMTE - Departamento de Quimica
13 BIA - Unité de recherche sur les Biopolymères, Interactions Assemblages
14 MSSM - Icahn School of Medicine at Mount Sinai [New York]
15 LIH - Luxembourg Institute of Health
16 ATK NOVI - Plant Protection Institute [Budapest]
17 Centro de Biotecnologia y Genomica de Plantas - Centre for Plant Biotechnology and Genomics
18 Teagasc Food Research Centre [Fermoy, Ireland]
19 Medizinische Universität Wien = Medical University of Vienna
20 EPI - Paul-Ehrlich-Institute - Federal Institute for Vaccines and Biomedicines
2 TNO
3 University of Belgrade [Belgrade]
4 UAlg - Universidade do Algarve
5 UMG - Università degli Studi "Magna Graecia" di Catanzaro = University of Catanzaro
6 EM2C - Laboratoire d'Énergétique Moléculaire et Macroscopique, Combustion
7 Department of Chemistry
8 UCM - Universidad Complutense de Madrid = Complutense University of Madrid [Madrid]
9 ISPA - Institute of Sciences of Food Production
10 CIAL - Instituto de Investigación en Ciencias de la Alimentación
11 Laboratory of Mass Spectrometry-GIGA-Proteomics
12 REQUIMTE - Departamento de Quimica
13 BIA - Unité de recherche sur les Biopolymères, Interactions Assemblages
14 MSSM - Icahn School of Medicine at Mount Sinai [New York]
15 LIH - Luxembourg Institute of Health
16 ATK NOVI - Plant Protection Institute [Budapest]
17 Centro de Biotecnologia y Genomica de Plantas - Centre for Plant Biotechnology and Genomics
18 Teagasc Food Research Centre [Fermoy, Ireland]
19 Medizinische Universität Wien = Medical University of Vienna
20 EPI - Paul-Ehrlich-Institute - Federal Institute for Vaccines and Biomedicines
Joana Costa
- Fonction : Auteur
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- ORCID : 0000-0001-7028-2873
Caterina Villa
- Fonction : Auteur
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- ORCID : 0000-0002-9471-3612
Tanja Cirkovic-Velickovic
- Fonction : Auteur
- PersonId : 802440
- ORCID : 0000-0003-2559-5234
Denise Schrama
- Fonction : Auteur
- PersonId : 802439
- ORCID : 0000-0003-0274-5957
Pedro Rodrigues
- Fonction : Auteur
- PersonId : 770787
- ORCID : 0000-0002-9668-1204
Laura Martín-Pedraza
- Fonction : Auteur
- PersonId : 802438
- ORCID : 0000-0003-3133-0662
Linda Monaci
- Fonction : Auteur
- PersonId : 799154
- ORCID : 0000-0001-5650-7909
Elena Molina
- Fonction : Auteur
- PersonId : 769960
- ORCID : 0000-0001-7918-7768
Gabriel Mazzucchelli
- Fonction : Auteur
- PersonId : 759723
- ORCID : 0000-0002-8757-8133
Isabel Mafra
- Fonction : Auteur
- PersonId : 802208
- ORCID : 0000-0001-5311-8895
Roberta Lupi
- Fonction : Auteur
- PersonId : 1095012
Daniel Lozano-Ojalvo
- Fonction : Auteur
- PersonId : 800783
- ORCID : 0000-0002-3524-2929
Colette Larré
- Fonction : Auteur
- PersonId : 765266
- ORCID : 0000-0001-9585-9536
- IdRef : 116296852
Julia Klueber
- Fonction : Auteur
- PersonId : 802437
- ORCID : 0000-0001-5763-1856
Cristina Bueno-Diaz
- Fonction : Auteur
- PersonId : 802436
- ORCID : 0000-0001-7872-8948
Araceli Diaz-Perales
- Fonction : Auteur
- PersonId : 800784
- ORCID : 0000-0002-1093-3627
Sara Benedé
- Fonction : Auteur
- PersonId : 802435
- ORCID : 0000-0002-9288-9438
Simona Lucia Bavaro
- Fonction : Auteur
- PersonId : 802434
- ORCID : 0000-0002-5820-8088
Annette Kuehn
- Fonction : Auteur
- PersonId : 802442
- ORCID : 0000-0003-0474-2135
Karin Hoffmann-Sommergruber
- Fonction : Auteur
- PersonId : 764725
- ORCID : 0000-0002-8830-058X
Thomas Holzhauser
- Fonction : Auteur
- PersonId : 802443
- ORCID : 0000-0002-7818-7261
Résumé
Key determinants for the development of an allergic response to an otherwise 'harmless' food protein involve different factors like the predisposition of the individual, the timing, the dose, the route of exposure, the intrinsic properties of the allergen, the food matrix (e.g. lipids) and the allergen modification by food processing. Various physicochemical parameters can have an impact on the allergenicity of animal proteins. Following our previous review on how physicochemical parameters shape plant protein allergenicity, the same analysis was proceeded here for animal allergens.
We found that each parameter can have variable effects, ranging on an axis from allergenicity enhancement to resolution, depending on its nature and the allergen. While glycosylation and phosphorylation are common, both are not universal traits of animal allergens. High molecular structures can favour allergenicity, but structural loss and uncovering hidden epitopes can also have a similar impact. We discovered that there are important knowledge gaps in regard to physicochemical parameters shaping protein allergenicity both from animal and plant origin, mainly because the comparability of the data is poor. Future biomolecular studies of exhaustive, standardised design together with strong validation part in the clinical context, together with data integration model systems will be needed to unravel causal relationships between physicochemical properties and the basis of protein allergenicity.