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Journal Articles Pediatric Research Year : 2021

Research priorities in pediatric parenteral nutrition: a consensus and perspective from ESPGHAN/ESPEN/ESPR/CSPEN

Mark Johnson
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Alexandre Lapillonne
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Jiri Bronsky
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Magnus Domellof
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Nicholas Embleton
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Silvia Iacobelli
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Frank Jochum
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Koen Joosten
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Sanja Kolacek
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Walter Mihatsch
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Sissel Moltu
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John Puntis
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Arieh Riskin
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Raanan Shamir
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Merit Tabbers
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Johannes van Goudoever
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Miguel Saenz de Pipaon
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Christian Braegger
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Wei Cai
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Cristina Campoy
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Virgilio Carnielli
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Tamas Decsi
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Mary Fewtrell
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Natasa Fidler Mis
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Axel Franz
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Olivier Goulet
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Corina Hartman
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Susan Hill
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Iva Hojsak
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Berthold Koletzko
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Janusz Ksiazyk
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Szimonetta Lohner
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Dieter Mesotten
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Krisztina Mihalyi
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Francis Mimouni
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Christian Mølgaard
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Antonia Nomayo
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Charles Picaud
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Christine Prell
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Thibault Senterre
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Venetia Simchowitz
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Peter Szitanyi
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Dirk Vlasselaers
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Chris van den Akker
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Anne van Kempen
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Sascha Verbruggen
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Jiang Wu
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Weihui Yan
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Abstract

Parenteral nutrition is used to treat children that cannot be fully fed by the enteral route. While the revised ESPGHAN/ ESPEN/ESPR/CSPEN pediatric parenteral nutrition guidelines provide clear guidance on the use of parenteral nutrition in neonates, infants, and children based on current available evidence, they have helped to crystallize areas where research is lacking or more studies are needed in order to refine recommendations. This paper collates and discusses the research gaps identified by the authors of each section of the guidelines and considers each nutrient or group of nutrients in turn, together with aspects around delivery and organization. The 99 research priorities identified were then ranked in order of importance by clinicians and researchers working in the field using a survey methodology. The highest ranked priority was the need to understand the relationship between total energy intake, rapid catch-up growth, later metabolic function, and neurocognitive outcomes. Research into the optimal intakes of macronutrients needed in order to achieve optimal outcomes also featured prominently. Identifying research priorities in PN should enable research to be focussed on addressing key issues. Multicentre trials, better definition of exposure and outcome variables, and long-term metabolic and developmental follow-up will be key to achieving this.
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hal-03595764 , version 1 (03-03-2022)

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Mark Johnson, Alexandre Lapillonne, Jiri Bronsky, Magnus Domellof, Nicholas Embleton, et al.. Research priorities in pediatric parenteral nutrition: a consensus and perspective from ESPGHAN/ESPEN/ESPR/CSPEN. Pediatric Research, 2021, pp.1-10. ⟨10.1038/s41390-021-01670-9⟩. ⟨hal-03595764⟩
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