This paper investigates the relationship between mindfulness and well-being within thecontext of compliance with prophylactic measures in the time of COVID-19. We conducted a large-scale survey among a representative sample of the French population. We measured mindfulness,using the Mindful Attention Awareness Scale, and the extent to which respondents were impactedby COVID-19 in terms of their mood and quality of sleep, as well as how they complied withprophylactic measures. Our results suggest that more mindful individuals were less negativelyimpacted by COVID-19 with regard to their sleep and mood. Concerning the prophylactic measures,we obtained mixed results: more mindful participants were more likely to respect lockdowns, physicaldistancing and to cough in their sleeves, but did not wash their hands, wear masks or avoid touchingtheir face more often than less mindful individuals..