Prevalence of Self-Reported Venous Thromboembolism and Cardiovascular Risk Factors in Patients with Ulcerative Colitis: The GETAID FOCUS Study - Archive ouverte HAL Access content directly
Journal Articles Digestive Diseases and Sciences Year : 2022

Prevalence of Self-Reported Venous Thromboembolism and Cardiovascular Risk Factors in Patients with Ulcerative Colitis: The GETAID FOCUS Study

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Lucas Guillo
Benjamin Pariente
  • Function : Author
Laurent Beaugerie
  • Function : Author
Phillipe Seksik
  • Function : Author
Anne Bourrier
  • Function : Author
Arnaud Bourrreille
  • Function : Author
Ariadne Desjeux
  • Function : Author
Guillaume Savoye
  • Function : Author
Stéphanie Auzou
  • Function : Author
Guillaume Cadiot
  • Function : Author
Alban Benezech
  • Function : Author
Nicolas Mathieu
  • Function : Author
Georgia Malamut
  • Function : Author
Karine Amouriaux
  • Function : Author
Hédia Brixi
  • Function : Author
Marion Simon
  • Function : Author
Daniel Benitah
  • Function : Author
Philippe Ah-Soune
  • Function : Author
Mathurin Fumery
Gilles Boschetti
  • Function : Author
Claire Gay
  • Function : Author
Mathias Vidon
  • Function : Author
Ginette Fotsing
  • Function : Author
Benoit Coffin
  • Function : Author
Cyrielle Gilletta
  • Function : Author
Jean Marie Reimund
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Marie Bonnet-Dodel
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Abstract

Background and aims: Patients with inflammatory bowel disease have an increased risk of venous thromboembolism (VTE) and cardiovascular disease (CVD). The study aims to determine the prevalence of CVD and VTE risk factors in a large population of patients with ulcerative colitis (UC). Methods: We conducted a cross-sectional study in 33 French and Belgium referral centers. A questionnaire was developed to explore self-reported risk factors for VTE and CVD, based on the latest international guidelines, in consecutive patients with UC. Results: A total of 1071 patients with UC were included. There were 539 women (50.3%), and the median age of patients was 44 years [32; 57]. The median disease duration was 10 years [6; 17]. In the cohort, 36.5% of patients reported no cardiovascular risk factor (CVRF) and 72% had ≤ 1 CVRF. Regarding cardiovascular risk markers (CVRM) 36.9% of patients reported no CVRM and 78% had ≤ 1 CVRM. Of the 1071 patients, 91.3% of patients reported no VTE strong risk factor and 96% had ≤ 1 VTE moderate risk factor. Conclusion: This is the first cohort specifically designed to assess both VTE and CVD risks in patients with UC. More than one third of patients with UC had no CVRF and around three quarters had ≤ 1 CVRF. In addition, more than nine out of ten patients had no VTE strong risk factor and ≤ 1 moderate risk factor. Physicians should be aware of these factors in their patients.
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Dates and versions

hal-03773089 , version 1 (08-09-2022)

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Lucas Guillo, Aurélien Amiot, Mélanie Serrero, Romain Altwegg, Xavier Roblin, et al.. Prevalence of Self-Reported Venous Thromboembolism and Cardiovascular Risk Factors in Patients with Ulcerative Colitis: The GETAID FOCUS Study. Digestive Diseases and Sciences, 2022, 67 (9), pp.4525-4532. ⟨10.1007/s10620-022-07445-4⟩. ⟨hal-03773089⟩
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