GENETIC PARAMETERS AND GENOME-WIDE ASSOCIATION STUDY OF RESISTANCE TO ACUTE HYPERTHERMIA IN RAINBOW TROUT - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Conference Papers Year : 2022

GENETIC PARAMETERS AND GENOME-WIDE ASSOCIATION STUDY OF RESISTANCE TO ACUTE HYPERTHERMIA IN RAINBOW TROUT

Abstract

Selective breeding is a promising solution to reduce fish farms vulnerability to heat peaks. Objectives of this study were to give a new insight on the genetic architecture of resistance to acute hyperthermia stress in rainbow trout. At 275 days post-fertilization, 1,384 fish were phenotyped for acute hyperthermia resistance and body weight. Challenged fish were genotyped for 57K SNP and their genotypes were imputed at high-density thanks to their parents being genotyped on a 665K SNP array. Heritability estimate of resistance to acute hyperthermia was 0.32 ± 0.04. This trait was genetically negatively correlated with body weight (-0.58 ± 0.17). The genome-wide association study revealed that resistance to acute hyperthermia is highly polygenic as altogether the 5 detected QTLs explained less than 5% of the genetic variance. The main QTL region explained 3% of the genetic variance and contained two candidate genes previously described to be associated with temperature resistance.

Domains

Animal genetics
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Dates and versions

hal-03779084 , version 1 (16-09-2022)

Identifiers

  • HAL Id : hal-03779084 , version 1

Cite

Henri Lagarde, Delphine Lallias, Pierre Patrice, Martin Prchal, Yoannah François, et al.. GENETIC PARAMETERS AND GENOME-WIDE ASSOCIATION STUDY OF RESISTANCE TO ACUTE HYPERTHERMIA IN RAINBOW TROUT. World Congress on Genetics Applied to Livestock Production, Jul 2022, Rotterdam, Netherlands. ⟨hal-03779084⟩
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