GENETIC PARAMETERS AND GENOME-WIDE ASSOCIATION STUDY OF RESISTANCE TO ACUTE HYPERTHERMIA IN RAINBOW TROUT
Résumé
Selective breeding is a promising solution to reduce fish farms vulnerability to heat peaks.
Objectives of this study were to give a new insight on the genetic architecture of resistance to
acute hyperthermia stress in rainbow trout. At 275 days post-fertilization, 1,384 fish were
phenotyped for acute hyperthermia resistance and body weight. Challenged fish were
genotyped for 57K SNP and their genotypes were imputed at high-density thanks to their
parents being genotyped on a 665K SNP array. Heritability estimate of resistance to acute
hyperthermia was 0.32 ± 0.04. This trait was genetically negatively correlated with body weight
(-0.58 ± 0.17). The genome-wide association study revealed that resistance to acute
hyperthermia is highly polygenic as altogether the 5 detected QTLs explained less than 5% of
the genetic variance. The main QTL region explained 3% of the genetic variance and contained
two candidate genes previously described to be associated with temperature resistance.
Domaines
Génétique animale
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2022_WCGALP_acute_hyperthermia_resistance_Vf.pdf (677.63 Ko)
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