Significance Statement In the management of natural resources and biodiversity, humans and nature have traditionally been considered as two distinct systems, one controlling the other. The concept of socio-ecosystems allows a more integrated approach, in which humans and nature are recognized as interdependent. However, this new perspective does not necessarily eliminate a distinction between humans and nature, or even a hierarchy of humans over nature. This chapter aims to raise awareness of the potential human–nature dualism in socio-ecosystem approaches. Other research fields have adopted different approaches regarding human–nature integration versus dualism, offering a window on the advantages and limitations of various positions. We also discuss how methodological choices are important to translate human–nature integration or dichotomy depending on the study aim.