Maternal deprivation and milk replacement affect the integrity of gray and white matter in the developing lamb brain - Archive ouverte HAL Access content directly
Journal Articles Developmental Neurobiology Year : 2022

Maternal deprivation and milk replacement affect the integrity of gray and white matter in the developing lamb brain

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Abstract

The psychoendocrine evaluation of lamb development has demonstrated that mater-nal deprivation and milk replacement alters health, behavior, and endocrine pro-files. While lambs are able to discriminate familiar and non-familiar conspecifics(mother or lamb), only lambs reared with their mother develop such clear social dis-crimination or preference. Lambs reared without mother display no preference for aspecific lamb from its own group. Differences in exploratory and emotional behav-iors between mother-reared and mother-deprived lambs have also been reported.As these behavioural abilities are supported by the brain, we hypothesize that rear-ing with maternal deprivation and milk replacement leads to altered brain develop-ment and maturation. To test this hypothesis, we examined brain morphometric andmicrostructural variables extracted from in vivo T1-weighted and diffusion-weightedmagnetic resonance images acquired longitudinally (1 week, 1.5 months, and 4.5months of age) in mother-reared and mother-deprived lambs. From the morphometricvariables the caudate nuclei volume was found to be smaller for mother-deprived thanfor mother-reared lambs. T1-weighted signal intensity and radial diffusivity werehigher for mother-deprived than for mother-reared lambs in both the white and graymatters. The fractional anisotropy of the white matter was lower for mother-deprivedthan for mother-reared lambs. Based on these morphometric and microstructuralcharacteristics we conclude that maternal deprivation delays and affects lamb braingrowth and maturation.
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Dates and versions

hal-03830179 , version 1 (26-10-2022)

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Scott A. Love, Emmanuelle Haslin, Manon Bellardie, Frédéric Andersson, Laurent Barantin, et al.. Maternal deprivation and milk replacement affect the integrity of gray and white matter in the developing lamb brain. Developmental Neurobiology, 2022, 82 (2), pp.214-232. ⟨10.1002/dneu.22869⟩. ⟨hal-03830179⟩
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