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Journal Articles Current Opinion in Behavioral Sciences Year : 2016

Dietary triglycerides as signaling molecules that influence reward and motivation

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Abstract

The reinforcing and motivational aspects of food are tied to the release of the dopamine in the mesolimbic system (ML). Free fatty acids from triglyceride (TG)-rich particles are released upon action of TG-lipases found at high levels in peripheral oxidative tissue (muscle, heart), but also in the ML. This suggests that local TG-hydrolysis in the ML might regulate food seeking and reward. Indeed, evidence now suggests that dietary TG directly target the ML to regulate amphetamine-induced locomotion and reward seeking behavior. Though the cellular mechanisms of TG action are unresolved, TG act in part through ML lipoprotein lipase, upstream of dopamine 2 receptor (D2R), and show desensitization in conditions of chronically elevated plasma TG as occur in obesity. TG sensing in the ML therefore represents a new mechanism by which chronic consumption of dietary fat might lead to adaptations in the ML and dysregulated feeding behaviors.

Dates and versions

hal-03887112 , version 1 (06-12-2022)

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Chloé Berland, Céline Cansell, Thomas Hnasko, Christophe Magnan, Serge Luquet. Dietary triglycerides as signaling molecules that influence reward and motivation. Current Opinion in Behavioral Sciences, 2016, 9, pp.126-135. ⟨10.1016/j.cobeha.2016.03.005⟩. ⟨hal-03887112⟩
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