This work aimed to understand the mechanical behavior of siliceous and calcareous sand materials under uniaxial confined compression loading at high stress levels. For this purpose, a series of quasi-oedometric compression tests were conducted on sand materials, to examine the effects of grain size, nature, and moisture contents on the soil crushability and the compression behavior, using an upgraded thick pressure vessel device that can reach mean stress up to 500 MPa. All samples were prepared using an aspect ratio of 1:1 (diameter: height), placed inside a high strength steel vessel, and compressed at a uniform axial displacement rate of 5 µm/s. The vessel is instrumented with multiple strain gauges allowing for the characterization of the hydrostatic and deviatoric behavior of each test. The results of quasi-oedometric tests, conducted on these types of sand, up to a passive confinement of 500 MPa, show that particle breakage is enhanced by the presence of water. It was noticed that, for siliceous sand, smaller particles break more than larger particles, and that the calcareous grains manifest a rapid response to axial stress compared to siliceous sand. Testing various soil properties shows a great potential to better characterize the sensitivity to breakage of soils. Lastly, a post-mortem analysis of samples before and after testing, using the X-ray micro-tomography technique, was applied to study the mechanical damage of sand specimens.