Human Placental Adaptive Changes in Response to Maternal Obesity: Sex Specificities - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement
Journal Articles International Journal of Molecular Sciences Year : 2023

Human Placental Adaptive Changes in Response to Maternal Obesity: Sex Specificities

Abstract

Maternal obesity is increasingly prevalent and is associated with elevated morbidity and mortality rates in both mothers and children. At the interface between the mother and the fetus, the placenta mediates the impact of the maternal environment on fetal development. Most of the literature presents data on the effects of maternal obesity on placental functions and does not exclude potentially confounding factors such as metabolic diseases (e.g., gestational diabetes). In this context, the focus of this review mainly lies on the impact of maternal obesity (in the absence of gestational diabetes) on (i) endocrine function, (ii) morphological characteristics, (iii) nutrient exchanges and metabolism, (iv) inflammatory/immune status, (v) oxidative stress, and (vi) transcriptome. Moreover, some of those placental changes in response to maternal obesity could be supported by fetal sex. A better understanding of sex-specific placental responses to maternal obesity seems to be crucial for improving pregnancy outcomes and the health of mothers and children.
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hal-04137924 , version 1 (22-06-2023)

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Esther Dos Santos, Marta Hita Hernández, Valérie Sérazin, François Vialard, Marie-Noëlle Dieudonné. Human Placental Adaptive Changes in Response to Maternal Obesity: Sex Specificities. International Journal of Molecular Sciences, 2023, 24, ⟨10.3390/ijms24119770⟩. ⟨hal-04137924⟩
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