Heart failure and cachexia - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement
Journal Articles ARCHIVES DES MALADIES DU COEUR ET DES VAISSEAUX. Year : 2006

Heart failure and cachexia

Abstract

Cachexia is related to a malnutrition state related to hypercatabolism. Initially described in cancer, it is also related to several chronic diseases including heart failure. Defined by an unintentional weight loss exceeding 7.5% of body mass during more than 6 months, it is presented by the association of nutritional deficiencies, digestive and/or urinary losses as well as metabolic abnormalities causing fat and lean mass loss and is associated to a poor prognosis. The pathophysiology of cachexia and heart failure presented some similarities associating especially neuro-hormonal activation, a cortisol/DHEA ratio imbalance, as well as pro-inflammatory cytokines activation. Currently the treatment of cachexia is mainly preventive, based on ACE-inhibitors and beta-blockers therapy and physical reconditioning. The benefits of hormonal and nutritional substitutes remains to be evidenced.

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Dates and versions

hal-04160698 , version 1 (12-07-2023)

Identifiers

  • HAL Id : hal-04160698 , version 1

Cite

J Y Tabet, P Meurin, a Ben Driss, D Logeart, Cécile Héliès-Toussaint, et al.. Heart failure and cachexia. ARCHIVES DES MALADIES DU COEUR ET DES VAISSEAUX., 2006, 99 (12), pp.1203-9. ⟨hal-04160698⟩
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