Codling moth Cydia pomonella L. is the most serious pest of apple and pear worldwide and causes damage and decreased yields. To minimize this risk, IPM tools can be applied to reduce the use of chemicals. A cost-effective application of IPM depends on the number of insects at the time of application. Several conditions and factors influence the lifecycle and numbers of generations within a year. In order to perform ex-ante evaluations of the cost-effectiveness of IPM measures against pest insects, the generic PREMISE insect model has been developed, which integrates insect's population dynamics, the climate and other conditions, applied measures, economics, environment and human health (residues). This paper describes these components of the PREMISE insect model, and how these components interact to assess the cost-effectiveness of IPM measures and the effects on the environment and human health. Codling moth is used as a case study for this generic model.