The interplay between dietary fatty acids and gut microbiota influences host metabolism and hepatic steatosis - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Nature Communications Year : 2023

The interplay between dietary fatty acids and gut microbiota influences host metabolism and hepatic steatosis

Hervé Guillou

Abstract

Dietary lipids can affect metabolic health through gut microbiota-mediated mechanisms, but the influence of lipid-microbiota interaction on liver steatosis is largely unknown. We investigate the impact of dietary lipids on human gut microbiota composition and the effects of microbiota-lipid interactions on steatosis in male mice. In humans, low intake of saturated fatty acids (SFA) is associated with increased microbial diversity independent of fiber intake. In mice, poorly absorbed dietary long-chain SFA, particularly stearic acid, induce a shift in bile acid profile and improved metabolism and steatosis. These benefits are dependent on the gut microbiota, as they are transmitted by microbial transfer. Diets enriched in polyunsaturated fatty acids are protective against steatosis but have minor influence on the microbiota. In summary, we find that diets enriched in poorly absorbed long-chain SFA modulate gut microbiota profiles independent of fiber intake, and this interaction is relevant to improve metabolism and decrease liver steatosis.
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hal-04197137 , version 1 (05-09-2023)

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Marc Schoeler, Sandrine Ellero-Simatos, Till Birkner, Jordi Mayneris-Perxachs, Lisa Olsson, et al.. The interplay between dietary fatty acids and gut microbiota influences host metabolism and hepatic steatosis. Nature Communications, 2023, 14 (1), pp.5329. ⟨10.1038/s41467-023-41074-3⟩. ⟨hal-04197137⟩
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