This study aimed to determine how within-plot soil heterogeneity combined with yearly climate variability can promote the heterogeneity of vine growth at plot level, and which soil-climate parameters influence final yield and berry composition the most. An 8-year experiment was conducted on grapevine in two zones of a vineyard (1 ha) differentiated according to grapevine vigour as determined by NDVI: high vigour (HV) and low vigour (LV). The heterogeneity of the soil properties (depth, texture and composition), plant growth (shoots and roots) and plant production (yield components and berry composition) were determined at plot level. Compared to the LV zone, the HV zone was associated with deeper soils, higher soil water and nitrogen availability, CEC and montmorillonite/illite ratio. More extended root systems, higher vegetative growth and higher yield were observed in the HV zone compared to the LV zone. Drier and warmer vintages increased the difference in heterogeneity of vine growth and yield between the two zones. Berry composition (primary and secondary metabolites) also differed between HV and LV zones but seemed unconnected to vigour and mainly depended on soil-climate-plant interactions over the years. The heterogeneity of plant vigour within the vineyard mainly resulted from differences in root exploration, soil profile and composition (notably montmorillonite/illite ratio). The present study identified soil and crop factors that, depending on weather conditions, can be drivers for reducing the heterogeneity of plant development and improving productivity at vineyard level.