Considered one of the five major threats to biodiversity worldwide, Invasive Alien Species (IAS) particularly threaten riparian ecosystems. Among the IAS found on riverbanks, Asian knotweeds ( Reynoutria spp. including R. japonica Houtt.; R. sachalinensis [F.Schmidt] Nakai and the hybrid R. x bohemica Chrtek & Chrtkova) can barely be controlled as, once established, they disperse easily along stream banks via rhizome or stem fragments transported by water. However, the hydrogeomorphological processes underlying the establishment of Asian knotweeds are poorly understood. The objective of this study was to describe and model the hydrogeomorphological preferences of Asian knotweeds along a Mediterranean river. Based on exhaustive presence/absence surveys, we implemented two models related to the presence of Asian knotweeds: (1) at the river reach scale and (2) at the finer scale of the alluvial bar. Areas of low curvature identified as convex banks and the central parts of alluvial bars appear to be more susceptible to knotweed establishment. Highly disturbed areas were less favorable to maintaining plant species, including Asian knotweeds, while less disturbed areas with denser plant cover were more favorable to Asian knotweeds. The results seem to indicate a trade‐off hypothesis in the knotweed establishment strategy between hydrogeomorphological constraints and strong interspecific competition. Analyzed in the light of the current literature, our final models are designed to integrate hydrogeomorphological processes in order to provide an operational tool to help river managers locate the areas most susceptible to knotweed invasion and with important implications for managing these species in riparian ecosystems.