Chapter 89 - Anaplasma
Résumé
Anaplasma phagocytophilum is a rickettsial pathogen transmitted by ixodid ticks. A. phagocytophilum colonizes myeloid and nonmyeloid cells and causes human granulocytic anaplasmosis—an important disease in the United States, Europe, and Asia. Research has illustrated how A. phagocytophilum successfully invades and proliferates inside host cells, causing a systemic disease. Major advances have been made in understanding the molecular interactions between A. phagocytophilum and host cells. Here, we address A. phagocytophilum biology and the underlying mechanisms involved in bacterial pathogenesis and vector–pathogen interactions. Clinical features, eco-epidemiology, diagnostics, and treatment are also discussed.