Alginate microgels encapsulation strategy of silver nanoparticles active against Candida albicans
Résumé
Nanoparticles (NPs), offering high specific surface, are considered as the best potential anti-microbial agents for a
wide range of medical nanotechnology. Among them, silver NPs (AgNPs) allow high biocidal activity. A design of
ecological capsules is proposed where AgNPs of 22 nm in diameter are grafted on the surface of biobased
nanocrystals obtained from cellulose (CNC) and chitin (ChiNC). These silver nanohybrids are dispersed in
calcium-alginate microgels of 45–50 μm in diameter using microfluidic tools. Such double level of immobilization
of AgNPs leads to highly stable carriers, prolongs shelf life and raises bioactivity, with a precise control of
well dispersed AgNPs as determined by scanning transmission electron microscopy, UV-Vis spectroscopy and
atomic absorption spectroscopy. Preliminary tests for antimicrobial activities of these new microgels have shown
a significant inhibitory effect on Candida albicans, the most common fungal pathogen, responsible for thrush and
vaginal yeast infections, for very low levels of silver.
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Licence : CC BY - Paternité
Licence : CC BY - Paternité