One of the solutions studied as part in the development of the bioeconomy is the use oflignocellulosic biomass through its main components: hemicelluloses, cellulose and lignin. Their valorisation asa carbon source for the production of biofuels, materials and other biochemical products requires apretreatment step, due to their recalcitrant complex three-dimensional structure which severely limits theirenzymatic degradation. To optimize this step and limit production costs of dilute acid pretreatment, an unprecedented data set of 38 pretreatment conditions (2-60 min, 120-190°C, 0-4%wt H2SO4) was generated, resulting in the analysis of 14gravimetric, chemical and spectral factors. This unique dataset, freely available, was explored using models and desirability functions. The results showthat it is possible to find trade-offs between cellulose integrity and hemicelluloses while limiting the productionof inhibitors: high temperatures, low acid contents and rapid treatments (2-10 min / 150-170°C / 0.8-2%H2SO4) or longer treatments at lower temperatures with more acid (50-60 min / 130-135°C / 2-3% H2SO4). Itwas also possible to highlight the links between production and degradation kinetics, through two maindegradation pathways: C5 and C6 sugars. The resulting reaction scheme, coupled with the calculation ofseverity in terms of CSF (Combined Severity Factor), can be considered as a decision support tool. Forexample, CSFs around 2 are a very good compromise for separating sugars while avoiding their degradation,and the use of a CSF slightly below 3 may be of interest for furfural production. This also allowed us to defineseverity limits between 1.5 and 3. Below this limit, hemicelluloses are not sufficiently degraded, while above,large amounts of inhibitors are produced.