The infant gut virome is associated with preschool asthma risk independently of bacteria - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Nature Medicine Year : 2023

The infant gut virome is associated with preschool asthma risk independently of bacteria

Cristina Leal Rodríguez
Shiraz Shah
Morten Arendt Rasmussen
Jonathan Thorsen
Ulrika Boulund
Casper-Emil Tingskov Pedersen
Josué Castro-Mejía
Christina Egeø Poulsen
  • Function : Author
Casper Sahl Poulsen
  • Function : Author
Ling Deng
Frej Andreas Nøhr Larsen
Michael Widdowson
Yichang Zhang
  • Function : Author
Søren Sørensen
Sylvain Moineau
Bo Chawes
Klaus Bønnelykke
Dennis Nielsen
Jakob Stokholm

Abstract

Bacteriophage (also known as phage) communities that inhabit the gut have a major effect on the structure and functioning of bacterial populations, but their roles and association with health and disease in early life remain unknown. Here, we analyze the gut virome of 647 children aged 1 year from the Copenhagen Prospective Studies on Asthma in Childhood2010 (COPSAC2010) mother-child cohort, all deeply phenotyped from birth and with longitudinally assessed asthma diagnoses. Specific temperate gut phage taxa were found to be associated with later development of asthma. In particular, the joint abundances of 19 caudoviral families were found to significantly contribute to this association. Combining the asthma-associated virome and bacteriome signatures had additive effects on asthma risk, implying an independent virome-asthma association. Moreover, the virome-associated asthma risk was modulated by the host TLR9 rs187084 gene variant, suggesting a direct interaction between phages and the host immune system. Further studies will elucidate whether phages, alongside bacteria and host genetics, can be used as preclinical biomarkers for asthma.

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hal-04557618 , version 1 (24-04-2024)

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Cristina Leal Rodríguez, Shiraz Shah, Morten Arendt Rasmussen, Jonathan Thorsen, Ulrika Boulund, et al.. The infant gut virome is associated with preschool asthma risk independently of bacteria. Nature Medicine, 2023, 30 (1), pp.138-148. ⟨10.1038/s41591-023-02685-x⟩. ⟨hal-04557618⟩
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