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Conference Papers Year : 2023

Structural and functional characterization of effector proteins to propose knowledge-driven plant resistance management

Abstract

The main strategy to control the fungus Leptosphaeria maculans, the causal agent of stem canker in Brassica napus, is genetic control by plant varieties carrying resistance (R) proteins. However, the massive deployment of a single source of resistance in the fields exerts strong selection pressures towards pathogen populations, leading to the rapid breakdown of the resistance. Recently, advances in effector repertoire prediction, in effector protein heterologous production and structural prediction algorithms have resulted in the identification of several effector families in L. maculans, these families being also present in other plant pathogenic fungi, mainly from the Dotheomycetes and Sordariomycetes. Furthermore, some of the structural analogues identified both in L. maculans and other plant pathogenic fungi share conserved functions during plant infection, suggesting an interesting evolutionary model. In addition, using transcriptomic data collected along the L. maculans life-cycle highlighted expression waves of distinct structural families, suggesting a striking coordination of them during the infection process. Here, we will review the recent advances in structural prediction / structure determination among L. maculans secretome and their implication to gain insight into the putative functions of candidate effectors. We will also propose possible strategies to improve resistance management or increase R proteins recognition spectrum using structural effector families.
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Dates and versions

hal-04565517 , version 1 (01-05-2024)

Identifiers

  • HAL Id : hal-04565517 , version 1

Cite

Clémentine Louet, Nacera Talbi, Inès Li de la Sierra-Gallay, Thierry Rouxel, Marie‐hélène Balesdent, et al.. Structural and functional characterization of effector proteins to propose knowledge-driven plant resistance management. International Congress of Plant Pathology, Aug 2023, Lyon, France. ⟨hal-04565517⟩
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