Computer-assisted semen analysis (CASA) systems are equipment that use different methodologies. When a laboratory wishes to acquire these systems, it is important to know how they perform. CASA has been “relegated” to the “advanced semen examinations” section in the latest version of the World Health Organization (WHO) lab manual because there is a lack of literature to demonstrate its full utility in routine infertility diagnosis. However, some systems perform very well in assessing sperm motility and sperm count. In the context of assisted reproductive techniques (ARTs), these systems save time and can provide a standardized assessment of the characteristics of semen prepared for ART. CASA systems are evolving steadily, artificial (AI) systems are being developed, and smartphone-based sperm analysis systems are now available for home analysis. It is clear that andrology and ART are rapidly changing fields, whereas AI and automation are only just beginning. But in a few years’ time, there is no doubt that these CASA systems should improve further and enable what the WHO manual has been calling for since 2010: greater reproducibility and standardization.