In the context of recycling organic waste products or irrigation by treated wastewaters (re-use), the fate of human and veterinary pharmaceuticals in agricultural soils and consequent ground-water contamination are influenced by many factors, including soil properties controlling sorption and dissipation processes (Verlicchi et al., 2015, Mejías et al., 2021, Rietra et al., 2022). Sorption coefficients are among the most sensitive parameters in models used for risk assessment. However, for different classes of pharmaceuticals, the variations in sorption among different soil types are poorly described and understood (Kodesova et al., 2015). Here we reviewed sorption parameters for different classes of pharmaceuticals and their variation with selected soil properties. We also evaluated the sorption isotherms for three pharmaceuticals, ofloxacin, tetracycline, diclofenac and a bactericide,  riclocarban and ten soils from temperate and tropical regions, and assessed the impact of soil properties on Freundlich equation parameters Kf and n. Batch experiments were set up adapting OECD protocol and using initial concentration ranges from 5 to 1000 μg/L. For strongly sorbed molecules, namely ofloxacin, tetracycline and triclocarban, there were strong technical constraints for the quantification of equilibrium concentrations by LC-MS-MS. We used this knowledge from both literature review and experimental data to build pedotransfer functions that allow predicting sorption parameters for a wide range of soils. Sorption of ionizable pharmaceuticals was, in many cases, highly affected by soil pH and CEC whereas soil organic matter content remained a driving factor of sorption for neutral molecular forms.References:Kodesova, R., et al. (2015) Science of the Total Environment 511, 435–443.Mejías, C. et al. (2021) Trends in Environmental Analytical Chemistry 30, e00125.Rietra, R.P.P.J., et al. (2024) Heliyon 10 (2024) e23718.Verlicchi, P. & Zambello, E., (2015) Science of The Total Environment 538, 750–767