Rickettsia helvetica in C3H/HeN mice: A model for studying pathogen-host interactions - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement
Journal Articles Heliyon Year : 2024

Rickettsia helvetica in C3H/HeN mice: A model for studying pathogen-host interactions

Abstract

While locally-acquired dengue virus (DENV) human infections occur in mainland France since 2010, data to identify the mosquito species involved and to trace the virus are frequently lacking. Supported by a local network gathering public health agencies and research laboratories, we analysed, in late summer 2023, mosquitoes from privately-owned traps within a French urban neighbourhood affected by a dengue cluster. The cluster, in Auvergne-Rhône-Alpes, comprised three cases, including two autochthonous ones. Upon return from a recent visit to the French Caribbean Islands, the third case had consulted healthcare because of dengue-compatible symptoms, but dengue had not been recognised. For the two autochthonous cases, DENV-specific antibodies in serum or a positive quantitative PCR for DENV confirmed DENV infection. The third case had anti-flavivirus IgMs. No DENV genetic sequences were obtained from affected individuals but Aedes albopictus mosquitoes trapped less than 200 m from the autochthonous cases’ residence contained DENV. Genetic data from the mosquito-derived DENV linked the cluster to the 2023–2024 dengue outbreak in the French Caribbean Islands. This study highlights the importance of raising mosquito-borne disease awareness among healthcare professionals. It demonstrates Ae. albopictus as a DENV vector in mainland France and the value of private mosquito traps for entomo−virological surveillance.

Dates and versions

hal-04711538 , version 1 (27-09-2024)

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Cite

Apolline Maitre, Lourdes Mateos-Hernandez, Tal Azagi, Angélique Foucault-Simonin, Sabine Rakotobe, et al.. Rickettsia helvetica in C3H/HeN mice: A model for studying pathogen-host interactions. Heliyon, 2024, 10 (18), pp.e37931. ⟨10.1016/j.heliyon.2024.e37931⟩. ⟨hal-04711538⟩
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