Phylogenetic study of the Cell Division Cycle 48 protein - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement
Conference Papers Year : 2024

Phylogenetic study of the Cell Division Cycle 48 protein

Ines, Damien
  • Function : Author
  • PersonId : 1228163
Claire Rosnoblet
  • Function : Author
  • PersonId : 1206638
Pierre-Emmanuel Courty

Abstract

The control of protein homeostasis, a balance between their synthesis and degradation, also called proteostasis, is essential for cell survival. The ubiquitin proteasome system (UPS) is a major actor in the selective degradation of misfolded proteins to preserve proteome balance. Any imbalance of the proteome, for instance triggered by a biotic stress, leads to an accumulation of misfolded proteins leading to proteotoxic stress that can induce cell death. In particular, during pathogenic microorganisms attack in plants, the protein degradation system associated with the UPS are strongly mobilized. However, their function in these processes is still poorly understood. Moreover, the involvement and regulation of the UPS system in the establishment of beneficial interactions have been little understood. We therefore propose to study and compare the involvement and regulation of UPS during the establishment of beneficial and pathogenic interactions in plants. For this purpose, we analysed the behavior of key actors of the UPS, such as proteasomal subunits and the Cdc48 ATPase, a member of the AAA+ ATPase enzyme family which segregates misfolded proteins from subcellular structures or protein complexes, and brings them to the proteasome to facilitate their recycling or degradation. To summarize, this work provides new information regarding the role of and more generally the UPS and its dynamic during plant-microbe interaction
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Dates and versions

hal-04732240 , version 1 (11-10-2024)

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  • HAL Id : hal-04732240 , version 1

Cite

Ines, Damien, Claire Rosnoblet, Pierre-Emmanuel Courty. Phylogenetic study of the Cell Division Cycle 48 protein. Forum des jeunes chercheurs, Jun 2024, Dijon, France. ⟨hal-04732240⟩
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