Tribbles expression in cumulus cells is related to oocyte maturation and fatty acid metabolism. - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Journal of Ovarian Research Year : 2014

Tribbles expression in cumulus cells is related to oocyte maturation and fatty acid metabolism.

Abstract

In mammals, the Tribbles family includes widely expressed serine-threonine kinase-like proteins (TRIB1, TRIB2 and TRIB3) that are involved in multiple biological processes including cell proliferation and fatty acid (FA) metabolism. Our recent studies highlighted the importance of FA metabolism in cumulus cells (CC) during oocyte maturation in vertebrates and reported a higher TRIB1 expression in CC surrounding in vivo mature oocytes as compared to immature ooocytes in mice and cows. The objective was to investigate Tribbles expression patterns in bovine CC during in vitro maturation (IVM) and to examine their roles in the cumulus-oocyte complex.
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Dates and versions

hal-00995701 , version 1 (23-05-2014)

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Daphné Brisard, Franck Chesnel, Sébastien Elis, A. Desmarchais, L. Sanchez-Lazo, et al.. Tribbles expression in cumulus cells is related to oocyte maturation and fatty acid metabolism.. Journal of Ovarian Research, 2014, 7 (1), pp.44. ⟨10.1186/1757-2215-7-44⟩. ⟨hal-00995701⟩
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