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Article dans une revue

Odorant receptors can mediate axonal identity and gene choice via cAMP-independent mechanisms

Abstract : Odorant receptors (ORs) control several aspects of cell fate in olfactory sensory neurons (OSNs), including singular gene choice and axonal identity. The mechanisms of OR-induced axon guidance have been suggested to principally rely on G-protein signalling. Here, we report that for a subset of OSNs, deleting G proteins or altering their levels of signalling does not affect axonal identity. Signalling-deficient ORs or surrogate receptors that are unable to couple to Gs/Golf still provide axons with distinct identities and the anterior-posterior targeting of axons does not correlate with the levels of cAMP produced by genetic modifications. In addition, we refine the models of negative feedback by showing that ectopic ORs can be robustly expressed without suppressing endogenous gene choice. In conclusion, our results uncover a new feature of ORs, showing that they can instruct axonal identity and regulate olfactory map formation independent of canonical G-protein signalling and cAMP production.
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Déposant : Csga - Université de Bourgogne <>
Soumis le : mardi 26 septembre 2017 - 22:10:56
Dernière modification le : jeudi 4 juin 2020 - 11:46:02
Archivage à long terme le : : mercredi 27 décembre 2017 - 17:39:57


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Kiavash Movahedi, Xavier Grosmaitre, Paul Feinstein. Odorant receptors can mediate axonal identity and gene choice via cAMP-independent mechanisms. Open Biology, Royal Society, 2016, 6 (7), pp.160018. ⟨10.1098/rsob.160018⟩. ⟨hal-01393703⟩



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