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Unraveling the effects of the gut microbiota composition and function on horse endurance physiology

Abstract : An integrated analysis of gut microbiota, blood biochemical and metabolome in 52 endurance horses was performed. Clustering by gut microbiota revealed the existence of two communities mainly driven by diet as host properties showed little effect. Community 1 presented lower richness and diversity, but higher dominance and rarity of species, including some pathobionts. Moreover, its microbiota composition was tightly linked to host blood metabolites related to lipid metabolism and glycolysis at basal time. Despite the lower fiber intake, community type 1 appeared more specialized to produce acetate as a mean of maintaining the energy supply as glucose concentrations fell during the race. On the other hand, community type 2 showed an enrichment of fibrolytic and cellulolytic bacteria as well as anaerobic fungi, coupled to a higher production of propionate and butyrate. The higher butyrate proportion in community 2 was not associated with protective effects on telomere lengths but could have ameliorated mucosal inflammation and oxidative status. The gut microbiota was neither associated with the blood biochemical markers nor metabolome during the endurance race, and did not provide a biomarker for race ranking or risk of failure to finish the race.
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https://hal-univ-evry.archives-ouvertes.fr/hal-02489982
Déposant : Univ Évry Hal <>
Soumis le : mercredi 26 février 2020 - 10:19:58
Dernière modification le : jeudi 15 octobre 2020 - 17:00:08

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s41598-019-46118-7.pdf
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Sandra Plancade, Allison Clark, Catherine Philippe, Jean-Christophe Helbling, Marie-Pierre Moisan, et al.. Unraveling the effects of the gut microbiota composition and function on horse endurance physiology. Scientific Reports, Nature Publishing Group, 2019, 9 (1), pp.9620. ⟨10.1038/s41598-019-46118-7⟩. ⟨hal-02489982⟩

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