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Independent elaboration of steroid hormone signaling pathways in metazoans

Abstract : Steroid hormones regulate many physiological processes in vertebrates, nematodes, and arthropods through binding to nuclear receptors (NR), a metazoan-specific family of ligand-activated transcription factors. The main steps controlling the diversification of this family are now well-understood. In contrast, the origin and evolution of steroid ligands remain mysterious, although this is crucial for understanding the emergence of modern endocrine systems. Using a comparative genomic approach, we analyzed complete metazoan genomes to provide a comprehensive view of the evolution of major enzymatic players implicated in steroidogenesis at the whole metazoan scale. Our analysis reveals that steroidogenesis has been independently elaborated in the 3 main bilaterian lineages, and that steroidogenic cytochrome P450 enzymes descended from those that detoxify xenobiotics.
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Submitted on : Sunday, May 31, 2020 - 9:30:27 AM
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Gabriel V Markov, Raquel Tavares, Chantal Dauphin-Villemant, Barbara A. Demeneix, Michael E. Baker, et al.. Independent elaboration of steroid hormone signaling pathways in metazoans. Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2009, 106 (29), pp.11913-11918. ⟨10.1073/pnas.0812138106⟩. ⟨hal-02666864⟩

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