Apoptotic mitochondrial dysfunction induced by benzo(a)pyrene in liver epithelial cells: role of p53 and pHi changes. - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement
Journal Articles Annals of the New York Academy of Sciences Year : 2003

Apoptotic mitochondrial dysfunction induced by benzo(a)pyrene in liver epithelial cells: role of p53 and pHi changes.

Abstract

How pH(i) changes, more specifically alkalinization, affect the apoptotic cascade has yet to be determined. The aim of the present work was to test the involvement of mitochondria in the apoptotic cascade triggered by benzo(a)pyrene [B(a)P] and to determine the role of pH(i) changes and p53 relative to mitochondria. Our results indicate that B(a)P-induced apoptosis might rely upon a p53-dependent and a pH-sensitive mitochondrial dysfunction.
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Dates and versions

hal-02681880 , version 1 (31-05-2020)

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Laurence Huc, David Gilot, Claire Gardyn, Mary Rissel, Marie-Thérèse Dimanche-Boitrel, et al.. Apoptotic mitochondrial dysfunction induced by benzo(a)pyrene in liver epithelial cells: role of p53 and pHi changes.. Annals of the New York Academy of Sciences, 2003, 1010, pp.167-70. ⟨hal-02681880⟩
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