A missed Fe-S cluster handoff causes a metabolic shakeup
Résumé
The general framework of pathways by which iron-sulfur (Fe-S) clusters are assembled in cells is well-known, but the cellular consequences of disruptions to that framework are not fully understood. Crooks et al. report a novel cellular system that creates an acute Fe-S cluster deficiency, using mutants of ISCU, the main scaffold protein for Fe-S cluster assembly. Surprisingly, the resultant metabolic reprogramming leads to the accumulation of lipid droplets, a situation encountered in many poorly understood pathological conditions, highlighting unanticipated links between Fe-S assembly machinery and human disease.
Domaines
Sciences du Vivant [q-bio]
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2018_Berteau_Journal of Biological Chemistry_1.pdf (285.07 Ko)
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