Early life stress in mice is a suitable model for Irritable Bowel Syndrome but does not predispose to colitis nor increase susceptibility to enteric infections - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Accéder directement au contenu
Article Dans Une Revue Brain, Behavior, and Immunity Année : 2018

Early life stress in mice is a suitable model for Irritable Bowel Syndrome but does not predispose to colitis nor increase susceptibility to enteric infections

Ambre Riba
  • Fonction : Auteur
Maïwenn Olier
Sonia Lacroix-Lamandé
Corinne Lencina
  • Fonction : Auteur
  • PersonId : 1204557
Cherryl Harkat
  • Fonction : Auteur
Marine Baron
  • Fonction : Auteur
Caroline Sommer
  • Fonction : Auteur
Virginie Mallet
  • Fonction : Auteur
Melissa Zill
  • Fonction : Auteur
Hervé Robert
  • Fonction : Auteur
  • PersonId : 1204939
Fabrice Laurent
Sandrine Ménard
Marion Gillet
  • Fonction : Auteur

Résumé

Neonatal period is characterized by an immature intestinal barrier. Scattered evidence suggests that early life stressful events induce long lasting alterations of intestinal homeostasis mimicking Irritable Bowel Syndrome (IBS). Those observations highlighting defect of intestinal barrier by early life stress questioned its potential role as a risk factor for gastrointestinal disorders such as colitis and infections. In this study, we aimed to analyze if maternal separation (MS) in mice gathers IBS main features. We next addressed whether MS could trigger or exacerbate colitis in genetically predisposed mice and/or enhance susceptibility to gastrointestinal infections in wild type mice. MS induced main features of IBS in adult wild type male mice i.e. intestinal hyperpermeability, visceral hypersensitivity, microbiota dysbiosis, bile acid malabsorption and low grade inflammation in intestine associated with a defect of Paneth cells and the ILC3 population. This breach in mucosal barrier functions in adults was associated with a systemic IgG response against commensal E. coli and increased IFNγ secretion by splenocytes. However, in IL10-/- mice, MS did not trigger nor worsen colitis. Furthermore, wild type mice submitted to MS did not show increase susceptibility to gastrointestinal infections (S. Typhimurium, L. monocytogenes or T. gondii) compared to controls. Altogether, our results identify MS in mice as a good experimental model for IBS mimicking all the main features. In addition, early life stress, even though it has long lasting consequences on intestinal homeostasis, does not constitute a facilitating factor to colitis in predisposed individuals nor to gastrointestinal infections in wild type mice.
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Dates et versions

hal-02621451 , version 1 (26-05-2020)

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Ambre Riba, Maïwenn Olier, Sonia Lacroix-Lamandé, Corinne Lencina, Valérie Alquier-Bacquié, et al.. Early life stress in mice is a suitable model for Irritable Bowel Syndrome but does not predispose to colitis nor increase susceptibility to enteric infections. Brain, Behavior, and Immunity, 2018, 73, pp.403-4015. ⟨10.1016/j.bbi.2018.05.024⟩. ⟨hal-02621451⟩
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